Glutathione peroxidase-1 gene knockout on body antioxidant defense in mice.

@article{Lei2001GlutathionePG,
  title={Glutathione peroxidase-1 gene knockout on body antioxidant defense in mice.},
  author={Xin Gen Lei},
  journal={BioFactors},
  year={2001},
  volume={14 1-4},
  pages={93-9}
}
To determine the in vivo role of cellular glutathione peroxidase (E.C.1.11.1.9, GPX1), we challenged the GPX1 knockout [GPX1(-/-)], the GPX1 overexpressing [GPX1(+)], and their respective wild-type (WT) mice of different Se and vitamin E status with acute oxidative stress. After these mice were injected with pro-oxidants paraquat or diquat at 12 to 125 mg/kg of body weight, their survival rate and time were a function of their GPX1 activity levels. The GPX1 protection was associated with… CONTINUE READING

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