Glutathione peroxidase 1 deficiency attenuates allergen-induced airway inflammation by suppressing Th2 and Th17 cell development.

@article{Won2010GlutathioneP1,
  title={Glutathione peroxidase 1 deficiency attenuates allergen-induced airway inflammation by suppressing Th2 and Th17 cell development.},
  author={Hee Yeon Won and Jung Ho Sohn and Hyun Jung Min and Kihyun Lee and Hyun Ae Woo and Ye-shih Ho and Jung Won Park and Sue-Goo Rhee and Eun Sook Hwang},
  journal={Antioxidants & redox signaling},
  year={2010},
  volume={13 5},
  pages={575-87}
}
Engagement of T cell receptor (TCR) triggers signaling pathways that mediate activation, proliferation, and differentiation of T lymphocytes. Such signaling events are mediated by reactive oxygen species (ROS), including hydrogen peroxide and lipid peroxides, both of which are reduced by glutathione peroxidase 1 (GPx1). We have now examined the role of GPx1 in the activation, differentiation, and functions of CD4(+) T helper (Th) cells. TCR stimulation increased the intracellular ROS… CONTINUE READING

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