Glutathione peroxidase: A selenoenzyme

@article{Floh1973GlutathionePA,
  title={Glutathione peroxidase: A selenoenzyme},
  author={Leopold Floh{\'e} and Wolfgang A. G{\"u}nzler and Hans Hartmut Schock},
  journal={FEBS Letters},
  year={1973},
  volume={32}
}
Selenoproteins of the glutathione system
TLDR
Being dispensable for survival, cGPx is nevertheless essential to maintain hydroperoxide homeostasis, as demonstrated by mimicking the development of Keshan disease in c GPx(−/−) mice.
Glutathione Peroxidase Activity as a Function of Dietary Selenomethionine
TLDR
Researchers performed studies that showed GSH peroxidase activity is proportional to dietary selenium, which provided additional evidence for the role of Se per mol of enzyme in the function of GSH each of enzyme.
Diversity of glutathione peroxidases.
REGULATION OF SELECTED SELENOPROTEINS IN PORCINE AND BOVINE SKELETAL MUSCLE
TLDR
The entire selenoproteins family has redox capability because Sec is located in the active site, and the role of Sel-N is still undefined with the exception of an involvement in muscle cell maturation and in muscular dystrophy when the gene encoding SepN is mutated.
A selenium-containing phospholipid-hydroperoxide glutathione peroxidase in Schistosoma mansoni.
TLDR
S. mansoni contains a scienoperoxidase sharing molecular mass, catalytic efficiency and substrate specificity with phospholipid-hydroperoxide glutathione per oxidase, dismantling the concept that those enzymes are unique to vertebrate organisms.
New roles for an old selenoenzyme: evidence from glutathione peroxidase-1 null and overexpressing mice.
TLDR
It is demonstrated that GPX1 protects against oxidative stress mediated by reactive oxygen species (ROS), and the physiologic importance of this protection varies with insult level and body Se status, and its metabolic functions extend beyond redox regulation.
Selenium-glutathione peroxidase and vitamin E
TLDR
Peroxidation inhibition was related to GSH peroxidase activity and the concentration of added GSH, and the stimulation of added peroxide was likewise inhibited as a function of GSHperoxid enzyme and GSH.
Some Functions of the Essential Trace Element, Selenium
TLDR
The importance of selenium in mammalian physiology was magnified by the discovery of its occurrence in a 5' deiodinase that converts the prothyroid hormone, tetraiodothyronine, to the active hormone, 3,5,3'-tri-iod Timothyronine (Berry et al., 1991) and this established a direct role of se lenium in eukaryotic developmental processes.
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When hemolyzates from erythrocytes of selenium-deficient rats were incubated in vitro in the presence of ascorbate or H2O2, added glutathione failed to protect the hemoglobin from oxidative damage.
Instrumentelle Neutronenaktivierungsanalyse von Gesteinen am Beispiel von 7 Standardgesteinen des US Geological Survey
By means of instrumental neutron-activation analysis the elements Sc, Cr, Co, Rb, Sb, Cs, La, Ce, Nd, Eu, Tb, Yb, Lu, Hf, Ta, and Th were determined in the standard rocks G-2, GSP-1, AGV-1, PCC-1,
Glutathione peroxidase, V. The kinetic mechanism.
:iTS; 7~-~Ce ~=~emon't~,i/-"]xxlman and alafirna] nialri~fi0n <Acade~n~c ~ress In-.ft. NeW~-~'~3~k an~t Loridon~
    ~nd L ~'lohe, Z. ph)'s~nl. ~nern. 333 {3972) 3~3BI-I~)D4
      Yle.r, S~rrapc~iurn o~ G~ha~atlaion~, 1~ Cengerencc of the 'Ge:8~]heh~ft ffir B~e,~og,~s~n~ Chum% Abs~aels