Glutathione peroxidase, glial cells and Parkinson's disease.

  title={Glutathione peroxidase, glial cells and Parkinson's disease.},
  author={Philippe Damier and Etienne C. Hirsch and P Zhang and Yves Agid and France Javoy-Agid},
  volume={52 1},
Hyperoxidation phenomena are suspected to be involved in dopaminergic cell death in Parkinson's disease, which affects preferentially the neuromelanin-containing dopaminergic neurons of the substantia nigra. Glutathione peroxidase is the major protective enzyme against hydrogen peroxide toxicity. The distribution of glutathione peroxidase-containing cells was investigated by immunohistochemistry in the midbrain of four control subjects and four patients with Parkinson's disease. (1) Glutathione… CONTINUE READING
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