Glutathione pathway genes and lung cancer risk in young and old populations.

@article{Yang2004GlutathionePG,
  title={Glutathione pathway genes and lung cancer risk in young and old populations.},
  author={Ping Yang and William R. Bamlet and Jon O. Ebbert and William R Taylor and Mariza de Andrade},
  journal={Carcinogenesis},
  year={2004},
  volume={25 10},
  pages={
          1935-44
        }
}
Multiple enzymes with overlapping functions and shared substrates in the glutathione (GSH) metabolic pathway have been associated with host susceptibility to tobacco smoke carcinogens and in lung cancer etiology. However, few studies have investigated the differing and interacting roles of GSH pathway enzymes with tobacco smoke exposure on lung cancer risk in young (<50 years of age) and old (>80 years of age) populations. Between 1997 and 2001, 237 primary lung cancer patients (170 young, 67… CONTINUE READING
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