Glutathione metabolism as a determinant of therapeutic efficacy: a review.

@article{Arrick1984GlutathioneMA,
  title={Glutathione metabolism as a determinant of therapeutic efficacy: a review.},
  author={Bradley A Arrick and Carl F Nathan},
  journal={Cancer research},
  year={1984},
  volume={44 10},
  pages={
          4224-32
        }
}
Glutathione, as the chief nonprotein intracellular sulfhydryl, affects the efficacy and interactions of a variety of antineoplastic interventions, mainly through nucleophilic thioether formation or oxidation-reduction reactions. Thus, glutathione plays a role in the detoxification and repair of cellular injury by such diverse agents as mechlorethamine, melphalan, cyclophosphamide, nitrosoureas, 6-thiopurine, 4'-(9-acridinylamino)methanesulfon-m-anisidide, the quinone antibiotics (including… CONTINUE READING

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