Glutathione levels and sensitivity to apoptosis are regulated by changes in transaldolase expression.

@article{Bnki1996GlutathioneLA,
  title={Glutathione levels and sensitivity to apoptosis are regulated by changes in transaldolase expression.},
  author={Katalin B{\'a}nki and Eliza Hutter and Emanuela Colombo and Nick J. Gonchoroff and Andr{\'a}s Perl},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 51},
  pages={32994-3001}
}
Transaldolase (TAL) is a key enzyme of the reversible nonoxidative branch of the pentose phosphate pathway (PPP) that is responsible for the generation of NADPH to maintain glutathione at a reduced state (GSH) and, thus, to protect cellular integrity from reactive oxygen intermediates (ROIs). Formation of ROIs have been implicated in certain types of apoptotic cell death. To evaluate the role of TAL in this process, Jurkat human T cells were permanently transfected with TAL expression vectors… CONTINUE READING