Glutathione levels and nerve cell loss in hippocampal cultures from trisomy 16 mouse--a model of Down syndrome.

@article{StabelBurow1997GlutathioneLA,
  title={Glutathione levels and nerve cell loss in hippocampal cultures from trisomy 16 mouse--a model of Down syndrome.},
  author={J Stabel-Burow and A Kleu and Sebastian Schuchmann and Uwe F Heinemann},
  journal={Brain research},
  year={1997},
  volume={765 2},
  pages={313-8}
}
The tripeptide glutathione (reduced state, GSH) is an important intracellular free radical scavenger protecting cells against oxidative stress. The trisomy 16 mouse is a model of the human trisomy 21 (Down syndrome). Here we demonstrate that cultured hippocampal neurons from trisomy 16 mouse exhibit decreased GSH levels and augmented cell death when… CONTINUE READING