Glutathione is required for efficient production of infectious picornavirus virions.

  title={Glutathione is required for efficient production of infectious picornavirus virions.},
  author={Allen D. Smith and Harry Dawson},
  volume={353 2},
Glutathione is an intracellular reducing agent that helps maintain the redox potential of the cell and is important for immune function. The drug L-buthionine sulfoximine (BSO) selectively inhibits glutathione synthesis. Glutathione has been reported to block replication of HIV, HSV-1, and influenza virus, whereas cells treated with BSO exhibit increased replication of Sendai virus. Pre-treatment of HeLa cell monolayers with BSO inhibited replication of CVB3, CVB4, and HRV14 with viral titers… CONTINUE READING


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