Glutathione-independent mechanism of apoptosis inhibition by curcumin in rat thymocytes.

  title={Glutathione-independent mechanism of apoptosis inhibition by curcumin in rat thymocytes.},
  author={Ewa Jaruga and Anna Bielak-Zmijewska and Ewa Sikora and Janusz S. Skierski and E Radziszewska and Katarzyna Piwocka and Grzegorz Bartosz},
  journal={Biochemical pharmacology},
  volume={56 8},
Curcumin (CUR) is a natural yellow dye with antioxidant and scavenging properties present in Curcuma species. It is widely used as an anti-inflammatory, anti-mutagenic and chemopreventive agent. In addition to its inhibitory effect on proliferation, CUR has recently been shown to block dexamethasone-induced programmed cell death (apoptosis) of rat thymocytes. Because cellular thiols seem to play a role in redox regulation of apoptosis, the mechanism of the anti-apoptotic effect of CUR was… CONTINUE READING
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