Glutathione in defense and signaling: lessons from a small thiol.

  title={Glutathione in defense and signaling: lessons from a small thiol.},
  author={Dale A. Dickinson and Henry Jay Forman},
  journal={Annals of the New York Academy of Sciences},
The mechanisms of thiol metabolism and chemistry have particular relevance to both cellular defenses against toxicant exposure and to redox signaling. Here, we will focus on glutathione (GSH), the major endogenous low- molecular-weight nonprotein thiol synthesized de novo in mammalian cells. The major pathways for GSH metabolism in defense of the cell are reduction of hydroperoxides by glutathione peroxidases (GSHPx) and some peroxiredoxins, which yield glutathione disulfide (GSSG), and… CONTINUE READING
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