Glutathione in cancer biology and therapy.

  title={Glutathione in cancer biology and therapy.},
  author={Jos{\'e} M Estrela and Angel Ortega and Elena Obrador},
  journal={Critical reviews in clinical laboratory sciences},
  volume={43 2},
The glutathione (GSH) content of cancer cells is particularly relevant in regulating mutagenic mechanisms, DNA synthesis, growth, and multidrug and radiation resistance. In malignant tumors, as compared with normal tissues, that resistance associates in most cases with higher GSH levels within these cancer cells. Thus, approaches to cancer treatment based on modulation of GSH should control possible growth-associated changes in GSH content and synthesis in these cells. Despite the potential… CONTINUE READING