Glutathione in Parkinson's disease: a link between oxidative stress and mitochondrial damage?

@article{Monte1992GlutathioneIP,
  title={Glutathione in Parkinson's disease: a link between oxidative stress and mitochondrial damage?},
  author={Donato A. Di Monte and Piu Chan and Martha S. Sandy},
  journal={Annals of neurology},
  year={1992},
  volume={32 Suppl},
  pages={S111-5}
}
Several links exist between the two mechanisms of neuronal degeneration (i.e., oxygen radical production and mitochondrial damage) proposed to have a role in Parkinson's disease. Indeed, mitochondria are critical targets for the toxic injury induced by oxygen radicals, and experimental evidence suggests that mitochondrial damage may cause an increased generation of oxygen radicals. A potentially important link between these two mechanisms of neurodegeneration is glutathione. Because of the… CONTINUE READING