Glutathione import in Haemophilus influenzae Rd is primed by the periplasmic heme-binding protein HbpA.

@article{Vergauwen2010GlutathioneII,
  title={Glutathione import in Haemophilus influenzae Rd is primed by the periplasmic heme-binding protein HbpA.},
  author={Bjorn Vergauwen and Jonathan Elegheert and Ann Dansercoer and Bart Devreese and Savvas N. Savvides},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 30},
  pages={13270-5}
}
Glutathione (GSH) is a vital intracellular cysteine-containing tripeptide across all kingdoms of life and assumes a plethora of cellular roles. Such pleiotropic behavior relies on a finely tuned spatiotemporal distribution of glutathione and its conjugates, which is not only controlled by synthesis and breakdown, but also by transport. Here, we show that import of glutathione in the obligate human pathogen Haemophilus influenzae, a glutathione auxotrophe, is mediated by the ATP-binding cassette… CONTINUE READING
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