Glutathione ester delays the onset of scurvy in ascorbate-deficient guinea pigs.

  title={Glutathione ester delays the onset of scurvy in ascorbate-deficient guinea pigs.},
  author={J M{\aa}rtensson and J Han and Owen W. Griffith and Alton Meister},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={90 1},
Previous studies showed that administration of ascorbate to glutathione (GSH)-deficient newborn rats and guinea pigs prevented toxicity and mortality and led to increased tissue and mitochondrial GSH levels; ascorbate thus spares GSH. In the present work, we tried to answer the converse question: Does administration of GSH spare ascorbate? Because administered GSH is not well transported into most cells, we gave GSH monoethyl ester (which is readily transported and converted into GSH… CONTINUE READING
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Methods Enzymol . 55 , 51 - 59

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