Glutathione elevation by γ‐glutamyl cysteine ethyl ester as a potential therapeutic strategy for preventing oxidative stress in brain mediated by in vivo administration of adriamycin: Implication for chemobrain

@article{Joshi2007GlutathioneEB,
  title={Glutathione elevation by γ‐glutamyl cysteine ethyl ester as a potential therapeutic strategy for preventing oxidative stress in brain mediated by in vivo administration of adriamycin: Implication for chemobrain},
  author={G. Joshi and Sarita S. Hardas and R. Sultana and D. S. St. Clair and M. Vore and D. Butterfield},
  journal={Journal of Neuroscience Research},
  year={2007},
  volume={85}
}
  • G. Joshi, Sarita S. Hardas, +3 authors D. Butterfield
  • Published 2007
  • Chemistry, Medicine
  • Journal of Neuroscience Research
  • Oxidative stress in heart and brain by the cancer chemotherapeutic drug adriamycin (ADR), used for treating solid tumors, is well established. Long‐term treatment with ADR in breast cancer patients has led to symptoms of cardiomyopathy. Less well recognized, but increasingly well documented, is cognitive dysfunction. After chemotherapy, free radical‐mediated oxidative stress has been reported in both heart and brain. We recently showed a significant increase in protein oxidation and lipid… CONTINUE READING
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    References

    SHOWING 1-10 OF 73 REFERENCES
    Free radical mediated oxidative stress and toxic side effects in brain induced by the anti cancer drug adriamycin: Insight into chemobrain
    • 150
    • PDF
    Elevation of brain glutathione by γ‐glutamylcysteine ethyl ester protects against peroxynitrite‐induced oxidative stress
    • 110
    • Highly Influential
    • PDF
    Adriamycin‐mediated nitration of manganese superoxide dismutase in the central nervous system: insight into the mechanism of chemobrain
    • 147
    • PDF
    Elevation of oxidative free radicals in Alzheimer's disease models can be attenuated by Ginkgo biloba extract EGb 761.
    • 204
    γ‐Glutamylcysteine ethyl ester protection of proteins from Aβ(1–42)‐mediated oxidative stress in neuronal cell culture: A proteomics approach
    • 42
    • PDF
    Antioxidants protect against reactive oxygen species associated with adriamycin-treated cardiomyocytes.
    • 86
    • PDF