Glutathione elevation by γ‐glutamyl cysteine ethyl ester as a potential therapeutic strategy for preventing oxidative stress in brain mediated by in vivo administration of adriamycin: Implication for chemobrain

@article{Joshi2007GlutathioneEB,
  title={Glutathione elevation by $\gamma$‐glutamyl cysteine ethyl ester as a potential therapeutic strategy for preventing oxidative stress in brain mediated by in vivo administration of adriamycin: Implication for chemobrain},
  author={Gururaj Joshi and Sarita S. Hardas and Rukhsana Sultana and Daret K. St. Clair and Mary Vore and David Allan Butterfield},
  journal={Journal of Neuroscience Research},
  year={2007},
  volume={85}
}
Oxidative stress in heart and brain by the cancer chemotherapeutic drug adriamycin (ADR), used for treating solid tumors, is well established. Long‐term treatment with ADR in breast cancer patients has led to symptoms of cardiomyopathy. Less well recognized, but increasingly well documented, is cognitive dysfunction. After chemotherapy, free radical‐mediated oxidative stress has been reported in both heart and brain. We recently showed a significant increase in protein oxidation and lipid… 
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