Glutathione depletion reverses cisplatin resistance in murine L1210 leukemia cells.

@article{Hromas1987GlutathioneDR,
  title={Glutathione depletion reverses cisplatin resistance in murine L1210 leukemia cells.},
  author={Robert Hromas and Paul A. Andrews and Michael P Murphy and Chapala P. Burns},
  journal={Cancer letters},
  year={1987},
  volume={34 1},
  pages={9-13}
}
Little is understood about the mechanism of acquired resistance to the widely used antineoplastic drug, cisplatin. The cisplatin-resistant murine leukemia L1210 cell line L1210/PAM has an elevated cellular glutathione content, as compared to its sensitive parent cell line, L1210/*. Exposure to D,L-buthionine-S,R-sulfoximine reduced L1210/PAM cells' glutathione content to nearly that of L1210/* cells and abrogated the resistance to cisplatin. 

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