Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis.

@article{Macho1997GlutathioneDI,
  title={Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis.},
  author={Antonio Macho and Tamara Hirsch and Isabel Marzo and Philippe Marchetti and Bruno Dallaporta and Santos A Susin and Naoufal Zamzami and Guido Kroemer},
  journal={Journal of immunology},
  year={1997},
  volume={158 10},
  pages={4612-9}
}
According to current understanding, several metabolic alterations form part of the common phase of the apoptosis process. Such alterations include a disruption of the mitochondrial transmembrane potential (delta psi(m)), a depletion of nonoxidized glutathione (GSH) levels, an increase in the production of reactive oxygen species (ROS), and an elevation in cytosolic free Ca2+ levels. Using a cytofluorometric approach, we have determined each of these parameters at the single cell level in… CONTINUE READING
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