Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells

@inproceedings{Sun2018GlutathioneDI,
  title={Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells},
  author={Yun Sun and Yingfeng Zheng and Chunxiao Wang and Yizhi Liu},
  booktitle={Cell Death & Disease},
  year={2018}
}
Glutathione (GSH) protects against oxidative damage in many tissues, including retinal pigment epithelium (RPE). Oxidative stress-mediated senescence and death of RPE and subsequent death of photoreceptors have been observed in age-related macular degeneration (AMD). Although the consequences of GSH depletion have been described previously, questions remain… CONTINUE READING