Glutathione depletion-induced chromosomal DNA fragmentation associated with apoptosis and necrosis.

@article{Higuchi2004GlutathioneDC,
  title={Glutathione depletion-induced chromosomal DNA fragmentation associated with apoptosis and necrosis.},
  author={Yoshihiro Higuchi},
  journal={Journal of cellular and molecular medicine},
  year={2004},
  volume={8 4},
  pages={455-64}
}
Chromosomal DNA and mitochondrial dysfunctions play a role on mammalian cell death induced by oxidative stress. The major biochemical dysfunction of chromosome is the presence of an ordered cleavage of the DNA backborn, which is separated and visualized as an electrophoretic pattern of fragments. Oxidative stress provides chromatin dysfunction such as single strand and double strand DNA fragmentation leading to cell death. More than 1 Mb of giant DNA, 200-800 kb or 50-300 kb high molecular… CONTINUE READING
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Glutathione depletion induces giant DNA fragmentation associated with apoptosis or necrosis

  • Y. Higuchi
  • 2001
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