Glutathione depletion and disruption of intracellular ionic homeostasis regulate lymphoid cell apoptosis.

@article{Franco2008GlutathioneDA,
  title={Glutathione depletion and disruption of intracellular ionic homeostasis regulate lymphoid cell apoptosis.},
  author={Rodrigo P. Franco and Wayne I Dehaven and Maria I Sifre and Carl D. Bortner and John Anthony Cidlowski},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 52},
  pages={36071-87}
}
Intracellular glutathione (GSH) depletion is an important hallmark of apoptosis. We have recently shown that GSH depletion by its extrusion regulates apoptosis independently of excessive reactive oxygen species accumulation. However, the mechanisms by which GSH depletion regulates apoptosis are still unclear. Because disruption of intracellular ionic homeostasis, associated with apoptotic volume decrease (AVD), is necessary for the progression of apoptotic cell death, we sought to evaluate the… CONTINUE READING
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