Glutathione-dependent dechlorination of 1,6-dichloro-1,6-dideoxyfructose.

  title={Glutathione-dependent dechlorination of 1,6-dichloro-1,6-dideoxyfructose.},
  author={H. M. Hughes and G. Powell and D. Snodin and J. Daniel and A. Crawford and J. K. Sanders and C. Curtis},
  journal={The Biochemical journal},
  volume={259 2},
  • H. M. Hughes, G. Powell, +4 authors C. Curtis
  • Published 1989
  • Chemistry, Medicine
  • The Biochemical journal
  • The metabolism of 14C- and 36Cl-labelled 1,6-dichloro-1,6-dideoxyfructose (DCF) was studied in the isolated perfused rat liver system. Dechlorination of DCF occurred in the liver and erythrocytes and was GSH-dependent. The GSH conjugate formed was identified by 13C and 1H n.m.r. as the 6-chlorofructos-1-yl-SG conjugate. It is proposed that the GS- anion attacks the low steady-state concentration of the reactive keto form of DCF and that the conjugate formed cyclizes to the dominant beta-anomer… CONTINUE READING
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