Glutathione deficiency increases hepatic ascorbic acid synthesis in adult mice.

@article{Mrtensson1992GlutathioneDI,
  title={Glutathione deficiency increases hepatic ascorbic acid synthesis in adult mice.},
  author={J M{\aa}rtensson and Alton Meister},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 23},
  pages={11566-8}
}
Glutathione deficiency, induced in adult mice by administering buthionine sulfoximine (an inhibitor of glutathione synthesis), led to a rapid and substantial increase in ascorbate in the liver. This effect was apparent 2-4 hr after giving the inhibitor; subsequently, the level of ascorbate decreased and that of dehydroascorbate increased markedly, supporting the conclusion that glutathione functions physiologically to keep ascorbate in its reduced form. In kidney and lung also, ascorbate levels… CONTINUE READING