Glutathione cycle activity and pyridine nucleotide levels in oxidant-induced injury of cells.

@article{Schraufsttter1985GlutathioneCA,
  title={Glutathione cycle activity and pyridine nucleotide levels in oxidant-induced injury of cells.},
  author={Ingrid U. Schraufst{\"a}tter and Daniel B Hinshaw and Paul A Hyslop and Roger G. Spragg and Charles G. Cochrane},
  journal={The Journal of clinical investigation},
  year={1985},
  volume={76 3},
  pages={1131-9}
}
Exposure of target cells to a bolus of H2O2 induced cell lysis after a latent period of several hours, which was prevented only when the H2O2 was removed within the first 30 min of injury by addition of catalase. This indicated that early metabolic events take place that are important in the fate of the cell exposed to oxidants. In this study, we described two early and independent events of H2O2-induced injury in P388D1 macrophagelike tumor cells: activation of the glutathione cycle and… CONTINUE READING