Glutathione conjugation of aflatoxin B1 exo- and endo-epoxides by rat and human glutathione S-transferases.

@article{Raney1992GlutathioneCO,
  title={Glutathione conjugation of aflatoxin B1 exo- and endo-epoxides by rat and human glutathione S-transferases.},
  author={Kevin D. Raney and David John Meyer and Brian Ketterer and Thomas M Harris and F Peter Guengerich},
  journal={Chemical research in toxicology},
  year={1992},
  volume={5 4},
  pages={
          470-8
        }
}
Much evidence supports the view that the rate of conjugation of glutathione (GSH) with aflatoxin B1 (AFB1) exo-epoxide is an important factor in determining the species variation in risk to aflatoxins and that induction of GSH S-transferases can yield a significant protective effect. An assay has been developed in which the enzymatic formation of the conjugates of GSH and AFB1 exo-epoxide and the recently described AFB1 endo-epoxide is measured directly. 1H NMR spectra are reported for both the… CONTINUE READING
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