Glutathione concentrations and glutathione S-transferase activity in human colonic neoplasms.

@article{Butler1994GlutathioneCA,
  title={Glutathione concentrations and glutathione S-transferase activity in human colonic neoplasms.},
  author={Ross N. Butler and Wendy J Butler and Z Moraby and Martin J. Fettman and Kevin K Khoo and Ian C. Roberts-Thomson},
  journal={Journal of gastroenterology and hepatology},
  year={1994},
  volume={9 1},
  pages={60-3}
}
Tissue concentrations of glutathione (GSH) and the activity of glutathione S-transferases (GST) are relevant to the inactivation of a variety of xenobiotics including carcinogens and anti-neoplastic drugs. In this study, GSH concentrations and GST activity were determined in 25 adenomatous polyps removed at colonoscopy, and in cancer and uninvolved 'normal' mucosa from 58 operative specimens containing colon cancer. We also examined the relationship between GSH concentrations, GST activity and… CONTINUE READING