Glutathione biosynthesis in the yeast pathogens Candida glabrata and Candida albicans: essential in C. glabrata, and essential for virulence in C. albicans.

@article{Yadav2011GlutathioneBI,
  title={Glutathione biosynthesis in the yeast pathogens Candida glabrata and Candida albicans: essential in C. glabrata, and essential for virulence in C. albicans.},
  author={Amit Kumar Yadav and Prashant Ramesh Desai and Maruti Nandan Rai and Rupinder Kaur and Kaliannan Ganesan and Anand Kumar Bachhawat},
  journal={Microbiology},
  year={2011},
  volume={157 Pt 2},
  pages={484-95}
}
Redox pathways play a key role in pathogenesis. Glutathione, a central molecule in redox homeostasis in yeasts, is an essential metabolite, but its requirements can be met either from endogenous biosynthesis or from the extracellular milieu. In this report we have examined the importance of glutathione biosynthesis in two major human opportunistic fungal pathogens, Candida albicans and Candida glabrata. As the genome sequence of C. glabrata had suggested the absence of glutathione transporters… CONTINUE READING

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