Glutathione availability modulates alveolar macrophage function in the chronic ethanol-fed rat.

@article{Brown2007GlutathioneAM,
  title={Glutathione availability modulates alveolar macrophage function in the chronic ethanol-fed rat.},
  author={Lou Ann Scism Brown and Xiao-Du Ping and Frank L. Harris and Theresa W. Gauthier},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2007},
  volume={292 4},
  pages={L824-32}
}
We have previously demonstrated that chronic alcohol exposure decreases glutathione in the alveolar space. Although alcohol use is associated with decreased alveolar macrophage function, the mechanism by which alcohol impairs macrophage phagocytosis is unknown. In the current study, we examined the possibility that ethanol-induced alveolar macrophage dysfunction was secondary to decreased glutathione and subsequent chronic oxidative stress in the alveolar space. After 6 wk of ethanol ingestion… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 49 extracted citations

Alcohol's Effects on Lung Health and Immunity.

Alcohol research : current reviews • 2015
View 4 Excerpts
Highly Influenced

Alcohol and the Lung

Alcohol research : current reviews • 2017
View 1 Excerpt

Thiol-Disulfide Exchange Reactions in the Mammalian Extracellular Environment.

Annual review of chemical and biomolecular engineering • 2016
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 33 references

The effects of chronic alcohol abuse on pulmonary glutathione homeostasis.

American journal of respiratory and critical care medicine • 2000

Similar Papers

Loading similar papers…