Glutathione availability modulates alveolar macrophage function in the chronic ethanol-fed rat.

  title={Glutathione availability modulates alveolar macrophage function in the chronic ethanol-fed rat.},
  author={Lou Ann Scism Brown and Xiao-Du Ping and Frank L. Harris and Theresa W. Gauthier},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  volume={292 4},
We have previously demonstrated that chronic alcohol exposure decreases glutathione in the alveolar space. Although alcohol use is associated with decreased alveolar macrophage function, the mechanism by which alcohol impairs macrophage phagocytosis is unknown. In the current study, we examined the possibility that ethanol-induced alveolar macrophage dysfunction was secondary to decreased glutathione and subsequent chronic oxidative stress in the alveolar space. After 6 wk of ethanol ingestion… CONTINUE READING


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