Glutathione and vitamin B₁₂ cooperate in stabilization of a B₁₂ trafficking chaperone protein.

@article{Park2012GlutathioneAV,
  title={Glutathione and vitamin B₁₂ cooperate in stabilization of a B₁₂ trafficking chaperone protein.},
  author={Jihyun Park and Jihoe Kim},
  journal={The protein journal},
  year={2012},
  volume={31 2},
  pages={
          158-65
        }
}
The protein bCblC (bCblCpro) is a bovine homolog of a human B₁₂ trafficking chaperone that is responsible for the processing of vitamin B₁₂ and its escorted delivery in intracellular B₁₂ metabolism. In this study, we found that bCblCpro is highly thermolabile with a T(m) = 42.0 ± 0.2 °C as shown for the human homolog, suggesting thermal regulation of these proteins. Binding of the reduced form of glutathione (GSH) that is a predominant cellular thiol increased the T(m) of bCblCpro from 42 °C to… CONTINUE READING
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