Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents

  title={Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents},
  author={Ying Hu and Sabine Urig and Sa{\vs}a Kon{\vc}arevi{\'c} and Xin-jiang Wu and Marina Fischer and Stefan Rahlfs and Volker Mersch-Sundermann and Katja Becker},
  booktitle={Biological chemistry},
Abstract We studied the effects of sulfur-containing chemopreventive agents, including allyl sulfides and isothiocyanates, on human redox networks. Isothiocyanates inhibited isolated redox-active enzymes in a time- and dose-dependent manner. As shown for the most active compound, benzyl isothiocyanate (BITC), on thioredoxin reductase, the inhibition has an initial competitive part (K i=6.1±1.0 μM) followed by a time-dependent irreversible inhibition (k 2=72.8±25.5 M -1 s-1). Also, glutathione… 

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