Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents.

@article{Hu2007GlutathioneAT,
  title={Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents.},
  author={Ying Hu and Sabine Urig and Sasa Koncarevic and Xinjiang Wu and Marina Fischer and Stefan Rahlfs and Volker Mersch-Sundermann and Katja Becker},
  journal={Biological chemistry},
  year={2007},
  volume={388 10},
  pages={1069-81}
}
We studied the effects of sulfur-containing chemopreventive agents, including allyl sulfides and isothiocyanates, on human redox networks. Isothiocyanates inhibited isolated redox-active enzymes in a time- and dose-dependent manner. As shown for the most active compound, benzyl isothiocyanate (BITC), on thioredoxin reductase, the inhibition has an initial competitive part (Ki=6.1+/-1.0 microM) followed by a time-dependent irreversible inhibition (k2=72.8+/-25.5 M(-1) s(-1)). Also, glutathione… CONTINUE READING

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