Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress.

@article{Hayes1999GlutathioneAG,
  title={Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress.},
  author={John D. Hayes and Lesley I. McLellan},
  journal={Free radical research},
  year={1999},
  volume={31 4},
  pages={
          273-300
        }
}
Increases in the intracellular levels of reactive oxygen species (ROS), frequently referred to as oxidative stress, represents a potentially toxic insult which if not counteracted will lead to membrane dysfunction, DNA damage and inactivation of proteins. Chronic oxidative stress has numerous pathological consequences including cancer, arthritis and neurodegenerative disease. Glutathione-associated metabolism is a major mechanism for cellular protection against agents which generate oxidative… CONTINUE READING
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