Glutathione and cysteines suppress cytotoxicity of gas phase of cigarette smoke by direct reacting with unsaturated carbonyl compounds in the gas phase.

@article{Higashi2019GlutathioneAC,
  title={Glutathione and cysteines suppress cytotoxicity of gas phase of cigarette smoke by direct reacting with unsaturated carbonyl compounds in the gas phase.},
  author={T. Higashi and Enas Elmeligy and Y. Mai and Y. Noya and K. Terada and Y. Mazaki and Y. Kuge and S. Miwa},
  journal={Biochemical and biophysical research communications},
  year={2019},
  volume={509 4},
  pages={
          988-993
        }
}
Unsaturated carbonyl compounds, such as acrolein (ACR) and methyl vinyl ketone (MVK), are environmental pollutants, and are contained in smoke, automobile exhaust, and heated oil. We have previously reported that major cytotoxic factors in the gas phase of cigarette smoke are ACR and MVK. ACR and MVK induce cell damage by reactive oxygen species generation via protein kinase C and NADPH oxidases, and antioxidants, such as glutathione (GSH) and N-acetylcysteine (NAC), can effectively suppress… Expand
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