Glutathione adducts of oxyeicosanoids.

@article{Murphy2002GlutathioneAO,
  title={Glutathione adducts of oxyeicosanoids.},
  author={Robert C Murphy and Simona Zarini},
  journal={Prostaglandins & other lipid mediators},
  year={2002},
  volume={68-69},
  pages={
          471-82
        }
}
Glutathione (GSH) is a major cellular antioxidant, which can conjugate chemically reactive, electrophilic molecules and thus, prevent unwanted reactions with important cell constituents. A large number of electrophilic eicosanoids, in particular alpha/beta-unsaturated ketones, are synthesized during arachidonic acid oxidative metabolism which can participate in the Michael addition reaction with GSH catalyzed by the GSH-S-transferase (GST) family. The structures of these adducts have been… CONTINUE READING
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