Glutathione S-transferases and cytochrome P450 detoxifying enzyme distribution in human cerebral glioma

  title={Glutathione S-transferases and cytochrome P450 detoxifying enzyme distribution in human cerebral glioma},
  author={Robert R Grant and James W Ironside},
  journal={Journal of Neuro-Oncology},
Malignant astrocytomas are frequently resistant to cytotoxic chemotherapy. A possible mechanism of chemoresistance is drug inactivation within malignant astrocytes by detoxifying enzymes (glutathione transferases (GST) and cytochrome P450's). The aim of this study was to assess whether there was differential expression of these detoxifying enzymes in the central nervous system and any relationship to histological grade (WHO) of the tumours. Immunostaining was performed in 30 consecutive glioma… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 15 extracted citations

Role of Glutathione-S-transferases in neurological problems.

Expert opinion on therapeutic patents • 2017
View 1 Excerpt

In vitro drug response and molecular markers associated with drug resistance in malignant gliomas.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2006

Genetic polymorphisms of glutathione S-transferases and the risk of adult brain tumors: a meta-analysis.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 2005
View 1 Excerpt


Publications referenced by this paper.
Showing 1-10 of 28 references

Age influences chemotherapy response in glioma, irrespective of tumor grade

R Grant, B Liang, M Page, H Greenberg, L Junck
Ann Neurol • 1992
View 1 Excerpt

Methods in Enzymology: Identification of P450s in the brain

M Warner, R Ahlgren, PG Zaphiropoulos, S-I Hayashi, J-A. Gustafsson
View 1 Excerpt

Significance of glutathione transferases in the resistance of tumor cells to alkylating cytostatic drugs

VM Castro
Doctorial dissertation Stockholm 1991, • 1991
View 1 Excerpt

Similar Papers

Loading similar papers…