Glutathione S-transferases and cytochrome P450 detoxifying enzyme distribution in human cerebral glioma

@article{Grant1995GlutathioneSA,
  title={Glutathione S-transferases and cytochrome P450 detoxifying enzyme distribution in human cerebral glioma},
  author={Robert R Grant and James W Ironside},
  journal={Journal of Neuro-Oncology},
  year={1995},
  volume={25},
  pages={1-7}
}
Malignant astrocytomas are frequently resistant to cytotoxic chemotherapy. A possible mechanism of chemoresistance is drug inactivation within malignant astrocytes by detoxifying enzymes (glutathione transferases (GST) and cytochrome P450's). The aim of this study was to assess whether there was differential expression of these detoxifying enzymes in the central nervous system and any relationship to histological grade (WHO) of the tumours. Immunostaining was performed in 30 consecutive glioma… CONTINUE READING

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