• Corpus ID: 19406156

Glutathione S-transferases and cancer (Review).

  title={Glutathione S-transferases and cancer (Review).},
  author={D Schipper and M J Wagenmans and D. J. Theo Wagener and Wilbert H. M. Peters},
  journal={International journal of oncology},
  volume={10 6},
Cytosolic glutathione S-transferases are a family of enzymes involved in the metabolism of drugs, toxins, carcinogens and also of anticancer drugs. Recent studies have indicated that glutathione S-transferases (GSTs) may play an important role in the resistance of cells to toxins and carcinogens but also to anticancer drugs. This report reviews the current literature concerning the role of glutathione S-transferases in anticancer drug resistance. Moreover, the significance of GST pi in… 

In vivo and in vitro inhibition of rat liver glutathione transferases activity by extracts from Combretum zeyheri (Combretaceae) and Parinari curatellifolia (Chrysobalanaceae)

The increased GST activity in vivo and versus inhibition in vitro suggests that metabolites may be responsible for the effects observed in vivo, and the inhibition of GST activity of by these two plants in vivo maybe one of the reasons that makes the plants important for use in the treatment pain and fever in ethnopharmacology.

Inactivation of Anopheles gambiae Glutathione Transferase ε2 by Epiphyllocoumarin

Tral 1, therefore, would produce irreversible effects when used together with dichlorodiphenyltrichloroethane (DDT) in malaria control programmes where resistance is mediated by GSTs.

Morphoproteomic confirmation of an activated nuclear factor-кBp65 pathway in follicular thyroid carcinoma.

Morphoproteomic analysis reveals the constitutive activation of the NF-кBp65 pathway in follicular thyroid carcinomas as evidenced by phosphorylation at Ser 536 with nuclear translocation and with correlative expression of transcriptionally activated gene products (COX-2, IL-8, and GST-pi).

Partial amino acid sequence and physiological effects of a 27 kDa parasitism‐specific protein present in the plasma of parasitized Lacanobia oleracea (Noctuidae)

Results suggest that it is most likely synthesized by host larvae in response to parasitism, and injected into L. oleracea larvae has no significant effect on their ability to gain weight or the time at which they pupate.