Glutathione S-transferase polymorphisms in osteosarcoma patients.

  title={Glutathione S-transferase polymorphisms in osteosarcoma patients.},
  author={Carolina Salinas-Souza and Ant{\^o}nio S{\'e}rgio Petrilli and S{\'i}lvia Regina Caminada de Toledo},
  journal={Pharmacogenetics and genomics},
  volume={20 8},
BACKGROUND Osteosarcoma is the most common malignant bone tumor in children and adolescents. Multidrug resistance and poor clinical outcome are the problems that still affect osteosarcoma patients. The glutathione S-transferase supergene family includes several genes that encode enzymes involved in the detoxification of many xenobiotic agents, including carcinogens and anticancer drugs. The polymorphisms in these genes have already been associated both with cancer susceptibility and anticancer… CONTINUE READING
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Introduction to pharmacogenomics: promises, opportunities, and limitations

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