Glutathione S-transferase polymorphisms and ovarian cancer treatment and survival.

Abstract

OBJECTIVE Members of the glutathione S-transferase (GST) family have been shown to have functional polymorphisms that may affect drug metabolism and influence the effects of chemotherapy and survival from cancer. GSTM1, GSTT1, and GSTP1 genotypes were evaluated for their role in ovarian cancer treatment and survival. METHODS DNA was extracted from tumor… (More)

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