Glutathione S-transferase pi (GSTP1) hypermethylation in prostate cancer: review 2007.

@article{Meiers2007GlutathioneSP,
  title={Glutathione S-transferase pi (GSTP1) hypermethylation in prostate cancer: review 2007.},
  author={Isabelle Meiers and Jonathan H. Shanks and David G. Bostwick},
  journal={Pathology},
  year={2007},
  volume={39 3},
  pages={299-304}
}
Prostatic carcinoma is characterised by the silencing of the pi-class glutathione S-transferase gene (GSTP1), which encodes a detoxifying enzyme. The silencing of GSTP1 results from aberrant methylation at the CpG island in the promoter-5' and occurs in the vast majority of cases of high-grade prostatic intraepithelial neoplasia (PIN) and prostate cancers. We review the potential novel role of GSTP1 and its related expression in prostate cancer. The loss of expression (silencing) of the GSTP1… CONTINUE READING

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