Glutathione S-transferase mu as a risk factor in bladder tumours.

  title={Glutathione S-transferase mu as a risk factor in bladder tumours.},
  author={Henrik Okkels and Torben Sigsgaard and Hans Julius Wolf and Herman Autrup},
  volume={6 3},
Glutathione transferases are involved in the detoxification of many zenobiotica involved in the etiology of cancer. To investigate the role of the glutathione S-transferase M1 deletion (GSTM1*0/0) in bladder carcinogenesis, the polymerase chain reaction was used to determine the GSTM1 genotypes of cancer patients (n = 234) and hospital controls (n = 202). Overall, the proportion of GSTM1*0/0 in the case group was 57%, compared to 50% in the control group giving an odds ratio (OR) of 1.33, (0.91… CONTINUE READING
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