Glutathione S-transferase hGSTM3 and ageing-associated neurodegeneration: relationship to Alzheimer's disease.

@article{Tchaikovskaya2005GlutathioneSH,
  title={Glutathione S-transferase hGSTM3 and ageing-associated neurodegeneration: relationship to Alzheimer's disease.},
  author={Tatyana Tchaikovskaya and Vadim E. Fraifeld and Tinatin Urphanishvili and John H Andorfer and Peter Davies and Irving Listowsky},
  journal={Mechanisms of ageing and development},
  year={2005},
  volume={126 2},
  pages={309-15}
}
Glutathione S-transferases (GSTs) are detoxification enzymes that can counter ageing-associated oxidative and chemical stresses. The transcript of a distinct subclass of human GSTs (hGSTM3) was shown by RNA blot analysis to be widely distributed in different regions of adult brain. HPLC profiles indicated that the hGSTM3 subunit was the second most abundant GST subunit in brain. Immunocytochemistry performed with hGSTM3-specific antisera, showed prominent staining of neuritic plaques… CONTINUE READING
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