Glutathione S-transferase and MRP1 form an integrated system involved in the storage and transport of dinitrosyl-dithiolato iron complexes in cells.

@article{Lok2014GlutathioneSA,
  title={Glutathione S-transferase and MRP1 form an integrated system involved in the storage and transport of dinitrosyl-dithiolato iron complexes in cells.},
  author={H. Lok and S. Sahni and V. Richardson and D. Kalinowski and Z. Kovacevic and D. Lane and D. Richardson},
  journal={Free radical biology \& medicine},
  year={2014},
  volume={75},
  pages={
          14-29
        }
}
Nitrogen monoxide (NO) is vital for many essential biological processes as a messenger and effector molecule. The physiological importance of NO is the result of its high affinity for iron in the active sites of proteins such as guanylate cyclase. Indeed, NO possesses a rich coordination chemistry with iron and the formation of dinitrosyl-dithiolato iron complexes (DNICs) is well documented. In mammals, NO generated by cytotoxic activated macrophages has been reported to play a role as a… Expand
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