Glutathione S-transferase M1 status and lung cancer risk: a meta-analysis.

  title={Glutathione S-transferase M1 status and lung cancer risk: a meta-analysis.},
  author={Richard S. Houlston},
  journal={Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology},
  volume={8 8},
Interindividual differences in lung cancer susceptibility may be mediated in part through polymorphic variability in the bioactivation of procarcinogens. GSTM1 status has been extensively studied in this context as a lung cancer risk factor, although published studies have produced conflicting results. To clarify the impact of GSTM1 status on lung cancer risk a meta-analysis of 23 case-control studies from the literature has been carried out using a random effects model. The principal outcome… CONTINUE READING


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