Glutathione S-transferase M1 and T1 null genotypes and the risk of gastric and colorectal cancers.

@article{Saadat2001GlutathioneSM,
  title={Glutathione S-transferase M1 and T1 null genotypes and the risk of gastric and colorectal cancers.},
  author={Iraj Saadat and Mostafa Saadat},
  journal={Cancer letters},
  year={2001},
  volume={169 1},
  pages={21-6}
}
Several polymorphic glutathione S-transferase (GST) enzymes are involved in the detoxification of active metabolites of many potential carcinogens and may therefore be important in modulating susceptibility to cancers. GSTM1 and GSTT1 are polymorphic, and the null alleles result in a lack of corresponding enzyme activities. Previous studies demonstrated that the GSTM1 and GSTT1 null genotypes correlated with an increased risk of developing some cancers. In this study, we determined GSTM1 and… CONTINUE READING
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