Glutathione S-transferase M1, T1, and P1 polymorphisms and prostate cancer risk in middle-aged men.


BACKGROUND The glutathione S-transferase (GST) enzymes detoxify several carcinogens. Genetic polymorphisms in GSTM1, T1, and P1 (Ile105Val) have been associated with prostate cancer, however, results have been inconsistent across studies. METHODS Data from a population-based case-control study in King County, Washington, were used to further evaluate the… (More)