Glutathione-S-transferase M1, M3, P1 and T1 polymorphisms and severity of lung disease in children with cystic fibrosis.

@article{Flamant2004GlutathioneStransferaseMM,
  title={Glutathione-S-transferase M1, M3, P1 and T1 polymorphisms and severity of lung disease in children with cystic fibrosis.},
  author={Cyril Flamant and Alexandra Henrion-Caude and Pierre-Yves Bo{\"e}lle and François Br{\'e}mont and Jacques Brouard and Bertrand Delaisi and J F Duhamel and Christophe Marguet and Michel Roussey and Marie-Claude Miesch and Mich{\'e}le Boul{\'e} and Richard C. Strange and Annick Cl{\'e}ment},
  journal={Pharmacogenetics},
  year={2004},
  volume={14 5},
  pages={295-301}
}
OBJECTIVES Progression and severity of lung disease differs markedly and early between patients with cystic fibrosis (CF). We investigated the hypothesis that polymorphisms in the detoxifying enzymes glutathione-S-transferase (GST) could influence phenotypic presentation of lung disease in CF. METHODS Genotypes for GSTM1, GSTM3, GSTP1 and GSTT1 were determined in a cohort of 146 children with CF by PCR-based methods. Pulmonary function, assessed by spirometric measures of forced expiratory… CONTINUE READING
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