Glutathione S-transferase GSTM1 phenotypes and protection against cutaneous tumours.

  title={Glutathione S-transferase GSTM1 phenotypes and protection against cutaneous tumours.},
  author={A H Heagerty and Desmond FitzGerald and A. Graham Smith and Bill Smith Bowers and Paul W. Jones and Anthony A Fryer and Liang Zhao and Julie E Alldersea and Richard C. Strange},
  volume={343 8892},
Multiple allelism at loci encoding detoxicating enzymes is associated with cancer risk. We have studied genetic variation at the glutathione S-transferase GSTM1 locus to see whether phenotypes confer altered susceptibility to basal cell carcinoma (BCC), squamous cell carcinoma (SCC), malignant melanoma (MM), or multiple skin tumours of different histological types. The frequency of GSTM1 null in cases and controls (52%) was similar, except for patients with two or more tumours of different… CONTINUE READING

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