Glutathione-S-transferase µ and theta gene polymorphisms as new risk factors of atopic bronchial asthma

@article{Ivaschenko2002GlutathioneStransferaseA,
  title={Glutathione-S-transferase µ and theta gene polymorphisms as new risk factors of atopic bronchial asthma},
  author={Tatanya E. Ivaschenko and O. G. Sideleva and Vladislav S. Baranov},
  journal={Journal of Molecular Medicine},
  year={2002},
  volume={80},
  pages={39-43}
}
The genetic polymorphism of glutathione-S-transferase M1 (GSTM1) and glutathione-S-transferase T1 (GSTT1) genes and the cytochrome P4501A1 gene responsible for xenobiotic conjugating enzymes of the phase II and phase I detoxification system were studied by PCR-RFLP in the blood spots of 109 patients with atopic bronchial asthma and 90 healthy individuals. GSTM1 gene deletion (GSTM10/0) was detected in 47.8% of individuals in the control group and in 76.1% of asthmatic patients. Individuals… CONTINUE READING

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