Glutathione S-transferase (GST) expression in the human hookworm Necator americanus: potential roles for excretory-secretory forms of GST.

@article{Brophy1995GlutathioneS,
  title={Glutathione S-transferase (GST) expression in the human hookworm Necator americanus: potential roles for excretory-secretory forms of GST.},
  author={Peter M. Brophy and Laurence H. Patterson and Alan Brown and David Idris Pritchard},
  journal={Acta tropica},
  year={1995},
  volume={59 3},
  pages={259-63}
}
The difficulty in demonstrating protective immunity to human gastro-intestinal nematodes is thought to be a consequence of the expression of defences by the parasites directed against the toxic metabolites of leukocytes produced during inflammation (Brophy and Pritchard, 1992a). Parasite glutathione S-transferases (GSTs) may provide part of this defence by detoxifying the secondary products of lipid peroxidation produced via immune initiated free-radical attack on host or parasite membranes… CONTINUE READING
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