Glutathione S-Transferase Omega 1-1 Is a Target of Cytokine Release Inhibitory Drugs and May Be Responsible for Their Effect on Interleukin-1β Posttranslational Processing

@inproceedings{Laliberte2003GlutathioneSO,
  title={Glutathione S-Transferase Omega 1-1 Is a Target of Cytokine Release Inhibitory Drugs and May Be Responsible for Their Effect on Interleukin-1β Posttranslational Processing},
  author={Ronald E Laliberte and David G. Perregaux and Lise R. Hoth and Philip J Rosner and Crystal K. Jordan and Kevin M Peese and James Frederick Eggler and Mark Anthony Dombroski and Kieran F. Geoghegan and Christopher A. Gabel},
  year={2003}
}
Abstract Stimulus-induced posttranslational processing of human monocyte interleukin-1β (IL-1β) is accompanied by major changes to the intracellular ionic environment, activation of caspase-1, and cell death. Certain diarylsulfonylureas inhibit this response, and are designated cytokine release inhibitory drugs (CRIDs). CRIDs arrest activated monocytes so that caspase-1 remains inactive and plasma membrane latency is preserved. Affinity labeling with [14C]CRIDs and affinity chromatography on… CONTINUE READING

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Tocopherol esters inhibit human glutathione S-transferase omega.

  • Acta biochimica Polonica
  • 2006
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